Some of the newer lines have a slightly different menu setup (D60, D300 [I think], D90?)... but even the older D80 style menu is still fairly intuitive. Some have dedicated ISO buttons, others, like my D60, have buttons that can be reprogrammed to do ISO or whatever you desire.
Never having shot with a newer Canon extensively, I'm not sure what tips to give you other than spending a few minutes getting used to the menus, modes, etc. Not a huge difference, I wouldn't think.
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